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Home - Products - Membrane Transporter/Ion Channel - Monocarboxylate Transporter - α-Cyano-4-hydroxycinnamic acid(α-CHCA)

α-Cyano-4-hydroxycinnamic acid(α-CHCA)

CAS No. 28166-41-8

α-Cyano-4-hydroxycinnamic acid(α-CHCA)( —— )

Catalog No. M20831 CAS No. 28166-41-8

α-Cyano-4-hydroxycinnamic acid (α-CHCA) is an inhibitor of monocarboxylate transporter 1 (MCT1) that blocks pyruvate transport in rat heart mitochondria (IC50 : 1.5 μM).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    α-Cyano-4-hydroxycinnamic acid(α-CHCA)
  • Note
    Research use only, not for human use.
  • Brief Description
    α-Cyano-4-hydroxycinnamic acid (α-CHCA) is an inhibitor of monocarboxylate transporter 1 (MCT1) that blocks pyruvate transport in rat heart mitochondria (IC50 : 1.5 μM).
  • Description
    α-Cyano-4-hydroxycinnamic acid (α-CHCA) is an inhibitor of monocarboxylate transporter 1 (MCT1) that blocks pyruvate transport in rat heart mitochondria (IC50 : 1.5 μM).
  • In Vitro
    α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) inhibits monocarboxylates transport such as lactate and pyruvate. α-Cyano-4-hydroxycinnamic acid (CHC; 0.5 mM and 1 mM) of 1 mM has a significant inhibitory effect on branching morphogenesis and decreases the epithelial perimeter and area of lung explants in a dose dependent way. ?At 100 μM concentration, α-Cyano-4-hydroxycinnamic acid rapidly and almost totally inhibits O2 uptake by rat heart mitochondria oxidizing pyruvate. Inhibition can be detected at concentrations of inhibitor as low as 1 μM although inhibition took time to develop at this concentration.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Monocarboxylate Transporter
  • Recptor
    MCT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    28166-41-8
  • Formula Weight
    189.17
  • Molecular Formula
    C10H7NO3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:37mg/mL(195.59mM)
  • SMILES
    N#C/C(=C\c1ccc(O)cc1)C(=O)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Miranda-Goncalves V Honavar M Pinheiro C et al. Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets[J]. Neuro-Oncology 2013 15(2):172-188.
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